Scientists discover stem cells in the womb lining causes women to suffer from recurrent miscarriages, a breakthrough that could lead to new treatments for the condition.
183 women donated tissue samples from the womb lining examined by scientists. They discovered, an epigenetic signature – which is typical of stem cells – was absent in cultures established from womb biopsies taken from women suffering recurrent miscarriages.
Compared to women in the study’s control group, fewer stem cells could be isolated from the lining of the womb from recurrent miscarriage patients.
“After an embryo has implanted, the lining of the uterus develops into a specialised structure called the decidua, and this process can be replicated when cells from the uterus are cultured in the lab,” said Brosens. “Cultured cells from women who had had three or more consecutive miscarriages showed that ageing cells in the lining of the womb don’t have the ability to prepare adequately for pregnancy,” Brosens added.
In a PR, Jane Brewin, CEO of pregnancy charity Tommy’s said,“Medical science doesn’t fully understand miscarriage which is why funding and research is so critical.” Adding, “Through pioneering medical research, Tommy’s clinicians will save babies’ lives by turning their discoveries into screening tests and treatments and launch clinics for pregnant women who are most at risk, giving them the latest improvements in care. They’ll share their work in national clinical guidelines, preventing miscarriages and developing better care across the country.”
The study was published in the journal Stem Cells.